Gefitinib-based PROTAC 3
Gefitinib-based PROTAC 3
CAS: 2230821-27-7
Molecular Formula: C47H57ClFN7O8S
Gefitinib-based PROTAC 3 - Names and Identifiers
| Name | Gefitinib-based PROTAC 3 |
| Synonyms | NTN21277 Gefitinib-based PROTAC 3 NTN21277(Gefitinib-based PROTAC 3) |
| CAS | 2230821-27-7 |
Gefitinib-based PROTAC 3 - Physico-chemical Properties
| Molecular Formula | C47H57ClFN7O8S |
| Molar Mass | 934.52 |
| Density | 1.300±0.06 g/cm3(Predicted) |
| Boling Point | 1065.6±65.0 °C(Predicted) |
| Solubility | DMSO : 60 mg/mL (64.20 mM) |
| pKa | 14.07±0.40(Predicted) |
| Storage Condition | 2-8°C |
Gefitinib-based PROTAC 3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.07 ml | 5.35 ml | 10.701 ml |
| 5 mM | 0.214 ml | 1.07 ml | 2.14 ml |
| 10 mM | 0.107 ml | 0.535 ml | 1.07 ml |
| 5 mM | 0.021 ml | 0.107 ml | 0.214 ml |
Last Update：2024-01-02 23:10:35
Gefitinib-based PROTAC 3 - Reference Information
| biological activity | Gefitinib-based PROTAC 3 coupling EGFR binding element with VHL ligand through connector can induce degradation of EGFR and its mutants. DC50 values in HCC827 (exon 19) and H3255(L858R) are 11.7 nM and 22.3 nM respectively. |
| target | TargetValue EGFR (in HCC827(Exon 19 del) cells) 11.7 nM(DC50) EGFR (in H3255 (L858R) cells) 22.3 nM(DC50) |
| Target | Value |
| EGFR (in HCC827(Exon 19 del) cells) | 11.7 nM(DC50) |
| EGFR (in H3255 (L858R) cells) | 22.3 nM(DC50) |
| use | EGFR binding element can be combined with VHL ligand through linker to act on HCC827 and H3255 cells to induce EGFR degradation. DC50 is 11.7nM and 22.3 nM respectively. |
Last Update：2024-04-09 21:31:57
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View History
Gefitinib-based PROTAC 3
2-氯-4-氰基嘧啶
cis-4-Hydroxycyclohexanecarboxylic Acid
2-IODOPROPANE (ISOPROPYL IODIDE )
2,6-二氟-3-硝基吡啶
LIPASE MML
ETHYL-3-AMINO-2.5-DICHLOROBENZOATE SOLUTION 100UG/ML IN MTBE 1ML
6-(1'-叔丁基二甲基硅氧乙基)-3-(2''-四氢呋喃基)-7-氧代-4-硫-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸烯丙酯
fosfonomycin
SBE-β-CD(Sulfobutyl Ether-β-cyclodextrin Sodium salt)
2-氯-4-氰基嘧啶
cis-4-Hydroxycyclohexanecarboxylic Acid
2-IODOPROPANE (ISOPROPYL IODIDE )
2,6-二氟-3-硝基吡啶
LIPASE MML
ETHYL-3-AMINO-2.5-DICHLOROBENZOATE SOLUTION 100UG/ML IN MTBE 1ML
6-(1'-叔丁基二甲基硅氧乙基)-3-(2''-四氢呋喃基)-7-氧代-4-硫-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸烯丙酯
fosfonomycin
SBE-β-CD(Sulfobutyl Ether-β-cyclodextrin Sodium salt)